| # | Pos. | Player | Date of Birth (Age) | Caps | Goals | Club |
|---|
| 1 | GK | Iker Casillas (captain) | 20 May 1981 (age 31) | 129 | 0 |  Real Madrid |
| 12 | GK | Víctor Valdés | 14 January 1982 (age 30) | 7 | 0 | Barcelona |
| 23 | GK | Pepe Reina | 31 August 1982 (age 29) | 24 | 0 |  Liverpool |
|
| 2 | DF | Raúl Albiol | 4 September 1985 (age 26) | 32 | 0 | Real Madrid |
| 3 | DF | Gerard Piqué | 2 February 1987 (age 25) | 38 | 4 | Barcelona |
| 4 | DF | Javi Martínez | 2 September 1988 (age 23) | 7 | 0 | Athletic Bilbao |
| 5 | DF | Juanfran | 9 January 1985 (age 27) | 1 | 0 | Atlético Madrid |
| 11 | DF | Jordi Alba | 21 March 1989 (age 23) | 4 | 0 | Valencia |
| 15 | DF | Sergio Ramos | 30 March 1986 (age 26) | 84 | 6 | Real Madrid |
| 17 | DF | Álvaro Arbeloa | 17 January 1983 (age 29) | 33 | 0 | Real Madrid |
|
| 6 | MF | Andrés Iniesta | 11 May 1984 (age 28) | 64 | 11 | Barcelona |
| 8 | MF | Xavi Hernández | 25 January 1980 (age 32) | 108 | 10 | Barcelona |
| 10 | MF | Cesc Fàbregas | 4 May 1987 (age 25) | 63 | 8 | Barcelona |
| 14 | MF | Xabi Alonso | 25 November 1981 (age 30) | 94 | 12 | Real Madrid |
| 16 | MF | Sergio Busquets | 16 July 1988 (age 23) | 38 | 0 | Barcelona |
| 20 | MF | Santi Cazorla | 13 December 1984 (age 27) | 41 | 5 | Málaga |
|
| 7 | FW | Álvaro Negredo | 20 August 1985 (age 26) | 8 | 5 | Sevilla |
| 9 | FW | Fernando Torres | 20 March 1984 (age 28) | 91 | 27 | Chelsea |
| 13 | FW | Juan Mata | 28 April 1988 (age 24) | 16 | 5 | Chelsea |
| 18 | FW | Pedro Rodríguez | 28 July 1987 (age 24) | 15 | 2 | Barcelona |
| 19 | FW | Fernando Llorente | 26 February 1985 (age 27) | 20 | 7 | Athletic Bilbao |
| 21 | FW | David Silva | 8 January 1986 (age 26) | 56 | 15 | Manchester City |
| 22 | FW | Jesús Navas | 21 November 1985 (age 26) | 16 | 1 | Sevilla |
